C₂₃H₂₉BrO₃SiZn

Base Information

• Chemical Name: C₂₃H₂₉BrO₃SiZn
• CAS No.: 1477482-21-5
• Molecular Formula: C₂₃H₂₉BrO₃SiZn
• Molecular Weight: 526.861
• Mol file: 1477482-21-5.mol

Synonyms:C₂₃H₂₉BrO₃SiZn

Chemical Property of C₂₃H₂₉BrO₃SiZn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₉BrO₃SiZn

There total 6 articles about C₂₃H₂₉BrO₃SiZn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H30O3Si (1477482-20-4) + zinc dibromide (7699-45-8) → C23H29BrO3SiZn (1477482-21-5)

Guidance literature:

C₂₃H₃₀O₃Si; With TurboGrignard; In tetrahydrofuran; at -10 ℃; for 1h;

zinc dibromide; In tetrahydrofuran; at -5 ℃; for 1h;

DOI:10.1055/s-0033-1339493

Reference yield:

3-(tert-butyldiphenylsilyloxy)propan-1-ol (127047-71-6) → C23H29BrO3SiZn (1477482-21-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: (R)-1,1'-Bi-2-naphthol; diethylzinc; titanium(IV) isopropylate / dichloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / 2 h / 20 °C

2.2: 12 h / 20 °C

3.1: potassium carbonate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C

4.2: 4 h / 20 °C

5.1: TurboGrignard / tetrahydrofuran / 1 h / -10 °C

5.2: 1 h / -5 °C

With titanium(IV) isopropylate; TurboGrignard; oxalyl dichloride; diethylzinc; (R)-1,1'-Bi-2-naphthol; tetra-(n-butyl)ammonium iodide; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; 1.2: |Swern Oxidation;

DOI:10.1055/s-0033-1339493

Reference yield:

3-(tert-butyldiphenylsilyloxy)-1-propanal (112897-03-7) → C23H29BrO3SiZn (1477482-21-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: (R)-1,1'-Bi-2-naphthol; diethylzinc; titanium(IV) isopropylate / dichloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / 2 h / 20 °C

1.2: 12 h / 20 °C

2.1: potassium carbonate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C

3.2: 4 h / 20 °C

4.1: TurboGrignard / tetrahydrofuran / 1 h / -10 °C

4.2: 1 h / -5 °C

With titanium(IV) isopropylate; TurboGrignard; diethylzinc; (R)-1,1'-Bi-2-naphthol; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;

DOI:10.1055/s-0033-1339493

upstream raw materials:

3-(tert-butyldiphenylsilyloxy)propan-1-ol

tert-butylchlorodiphenylsilane

3-(tert-butyldiphenylsilyloxy)-1-propanal

(S)-5-((tert-butyldiphenylsilyl)oxy)-1-(trimethylsilyl)pent-1-yn-3-ol

Downstream raw materials:

C₄₃H₅₂O₆SSi