2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester

Base Information

• Chemical Name: 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester
• CAS No.: 144313-89-3
• Molecular Formula: C₂₄H₃₂O₃S
• Molecular Weight: 400.582
• Mol file: 144313-89-3.mol

Synonyms:2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester

Chemical Property of 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester

There total 4 articles about 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-thiophenecarboxaldehyde (29421-72-5) → 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester (144313-89-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Mg / 1.) THF, 0 deg C, 2.) THF, reflux, 1 h

2: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 1 h / Ambient temperature

3: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

4: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

With potassium hydroxide; sodium acetate; tin(IV) chloride; hydrazine hydrate; magnesium; pyridinium chlorochromate; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00095a011

Reference yield:

1-(5-Methyl-thiophen-3-yl)-3-phenyl-propan-1-one (144313-87-1) → 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester (144313-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

2: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

With potassium hydroxide; tin(IV) chloride; hydrazine hydrate; In 1,2-dichloro-ethane;

DOI:10.1021/jm00095a011

Reference yield:

1-(5-Methyl-thiophen-3-yl)-3-phenyl-propan-1-ol (144313-86-0) → 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester (144313-89-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

3: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

With potassium hydroxide; sodium acetate; tin(IV) chloride; hydrazine hydrate; pyridinium chlorochromate; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00095a011

upstream raw materials:

ethyl 6-(chloroformyl)-2-methylhexanoate

2-methyl-4-(3-phenylpropyl)thiophene

2-methyl-4-thiophenecarboxaldehyde

1-(5-Methyl-thiophen-3-yl)-3-phenyl-propan-1-one

Downstream raw materials:

2-methyl-7-<5-methyl-3-(3-phenylpropyl)-2-thienyl>heptanoic acid