{3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Base Information

Chemical Name:{3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester
CAS No.:1329167-28-3
Molecular Formula:C₂₀H₂₅BrN₄O₄
Molecular Weight:465.347
Hs Code.:

Synonyms:{3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

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Chemical Property of {3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

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Technology Process of {3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

There total 1 articles about {3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1329167-28-3
{3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Guidance literature:

Reference yield: 64.0%

: 1329167-28-3
{3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1329167-29-4
tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

Guidance literature:: With N-Methyldicyclohexylamine; In tetrahydrofuran; at 0 - 20 ℃; for 20h;

Reference yield:

: 1329167-28-3
{3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

: 1329169-69-8
(6S)-6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Methyldicyclohexylamine / tetrahydrofuran / 20 h / 0 - 20 °C

2.1: potassium carbonate; ammonium hydroxide; L-proline; copper(l) iodide / dimethyl sulfoxide / 20 h / 85 °C / Inert atmosphere

3.1: triethylamine / ethyl acetate / 1 h / 0 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 1.17 h / 40 °C / Inert atmosphere

4.2: 40 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / Inert atmosphere

With ammonium hydroxide; copper(l) iodide; N-Methyldicyclohexylamine; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; L-proline; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;