tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

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Chemical Name:tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate
CAS No.:1329167-29-4
Molecular Formula:C₂₆H₃₉BrN₄O₅Si
Molecular Weight:595.609
Hs Code.:

Synonyms:tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

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Chemical Property of tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

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Technology Process of tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

There total 3 articles about tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1329167-28-3
{3-bromo-4-[2-((S)-1-tert-butoxycarbonylaminobut-3-enyl)-3H-imidazol-4-yl]phenyl}carbamic acid methyl ester

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1329167-29-4
tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

Guidance literature:: With N-Methyldicyclohexylamine; In tetrahydrofuran; at 0 - 20 ℃; for 20h;

Reference yield: 51.0%

: tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1329167-29-4
tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

: tert-butyl N-[(1S)-1-{4-[2-bromo-4-(9,9-dimethyl-3-oxo-2,6-dioxa-4-aza-9-siladecan-4-yl)phenyl]-1-{[2-(trimethylsilyl)-ethoxy]methyl}-1H-imidazol-2-yl}but-3-en-1-yl]carbamate

Guidance literature:: tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.6b01460