3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl p-toluenesulfonate

Base Information

Chemical Name:3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl p-toluenesulfonate
CAS No.:124937-99-1
Molecular Formula:C₃₀H₃₀O₄S
Molecular Weight:486.632
Hs Code.:
DSSTox Substance ID:DTXSID701172081

Synonyms:SCHEMBL4057724;DTXSID701172081;3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl p-toluenesulfonate;124937-99-1

Suppliers and Price of 3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl p-toluenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl p-toluenesulfonate

Chemical Property:

XLogP3:7.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:486.18648061
Heavy Atom Count:35
Complexity:696

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCCC(C2=CC=CC=C2)C3=C(C=CC(=C3)C)OCC4=CC=CC=C4

Technology Process of 3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl p-toluenesulfonate

There total 3 articles about 3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 854306-68-6
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol

: 98-59-9
p-toluenesulfonyl chloride

: 124937-99-1
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate

Guidance literature:: 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol; p-toluenesulfonyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h;

With hydrogenchloride; In dichloromethane; water; at 0 ℃;

Reference yield:

: 854306-68-6
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol

: 124937-99-1
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate

Guidance literature:: 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol; With triethylamine; In dichloromethane; at 25 - 35 ℃; for 0.166667 - 0.333333h;

With p-toluenesulfonyl chloride; In dichloromethane; at 25 - 35 ℃; for 10 - 12h;

With hydrogenchloride; In dichloromethane; water; for 0.333333 - 0.416667h;

Reference yield:

: 854306-67-5
methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate

: 124937-99-1
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 25 - 35 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 35 °C

With N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/op050024w