854306-68-6

Basic information

• Product Name: 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol
• Synonyms: 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol
• CAS NO: 854306-68-6
• Molecular Weight: 332.442
• Mol File: 854306-68-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol(854306-68-6)
• EPA Substance Registry System: 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol(854306-68-6)

Safety Data

• Hazardous Substances Data: 854306-68-6(Hazardous Substances Data)

Upstream product

• 851789-43-0 3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 854306-67-5 methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate 

Downstream Products

• 854306-69-7 N-isopropyl-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropylamine 
• 480432-14-2 N-isopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine 
• 854306-70-0 3-(2-(benzyloxy)-5-methylphenyl)-N-(3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropyl)-N-isopropyl-3-phenylpropan-1-amine 
• 854306-71-1 N-(3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropyl)-N-isopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropan-1-amine 
• 854306-72-2 bis{4-methyl-2-(3-phenylpropyl)phenol} 
• 156755-37-2 {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol 
• 214601-54-4 (R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl-propyl)-phenyl]-methanal 
• 848768-06-9 (R)-3-[2-(benzyloxy)-5-methylphenyl]-N,N-diisopropyl-3-phenylpropan-1-amine 
• 124937-52-6 tolterodine tartrate 
• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 
• 389068-22-8 N,N-diisopropyl-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropylamine 
• 124937-99-1 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate 

Relevant articles and documents

Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand

We hypothesized that if drug localization can be restricted to a particular subcellular domain where their target proteins reside, the drugs could bind to their target proteins without being metabolized and/or excreted, which would significantly extend the half-life of the corresponding drug-target complex. Thus, we designed ligand-phospholipid conjugates in which the ligand is conjugated with a phospholipid through a polyethylene glycol linker to restrict the subcellular localization of the ligand in the vicinity of the lipid bilayer. Here, we present the design, synthesis, pharmacological activity, and binding mode analysis of ligand-phospholipid conjugates with muscarinic acetylcholine receptors as the target proteins. These results demonstrate that ligand-phospholipid conjugation can be a versatile strategy for developing long-acting ligands that bind to membrane proteins in drug discovery.

Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine

A process is described for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine comprising substitution of the sulfonyloxy group of the compound of the formula in which the substituents R and R″ have the meanings stated in the description, in a solvent comprising an ionic liquid, to yield the tertiary amine of the formula and the subsequent deprotection thereof.

TOLTERODINE, COMPOSITIONS AND USES THEREOF, AND PREPARATION OF THE SAME

Racemic tolterodine free base in crystalline form, tolterodine with improved purity, compositions and uses thereof, and processes of preparing the same.