IMAZODAN

Base Information

• Chemical Name: IMAZODAN
• CAS No.: 84243-58-3
• Molecular Formula: C13H12N4O
• Molecular Weight: 240.264
• Hs Code.: 2933990090
• Mol file: 84243-58-3.mol

Synonyms:CI 914;Imazodan;

Chemical Property of IMAZODAN

Chemical Property:

• Melting Point: 218℃
• Refractive Index: 1.696
• PSA: 59.28000
• Density: 1.34g/cm³
• LogP: 1.25080
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO: 50 mg/mL, clear, yellow

Purity/Quality:

98%Min ^*data from raw suppliers

Imazodan ≥99% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Cardiotonic.

Technology Process of IMAZODAN

There total 6 articles about IMAZODAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid (84243-57-2) → imazodan (84243-58-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 7h; Heating;

DOI:10.1021/jm00148a006

Reference yield:

4-(4-fluorophenyl)-4-oxopropionic acid (366-77-8) → imazodan (84243-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylsulfoxide / 17 h / 100 °C

2: hydrazine / ethanol

With sodium hydride; hydrazine; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00375a001

Reference yield:

fluorobenzene (462-06-6) → imazodan (84243-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / CH₂Cl₂

2: NaH / dimethylsulfoxide / 17 h / 100 °C

3: hydrazine / ethanol

With aluminium trichloride; sodium hydride; hydrazine; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm00375a001

upstream raw materials:

4-(1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid

fluorobenzene

4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid

α-<4-(1H-imidazol-1-yl)phenyl>-4-morpholineacetonitrile

Downstream raw materials:

6-<4-(1H-imidazole-1-yl)phenyl>-3(2H)-pyridazinone

4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone

Refernces

• 1、 -. "Method of treating heart failure and medicaments therefor". . . Retrieved 2008/06/13.
• 2、 Bristol, James A.,Sircar, Ila,Moos, Walter H.,Evans, Dale B.,Weishaar, Ronald E.. "Cardiotonic Agents. 1. 4,5-Dihydro-6--3(2H)-pyridazinones: Novel Positive Inotropic Agents for the Treatment of Congestive Heart Failure". . p. 1099 - 1101. Retrieved 2007/10/02.