(2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Base Information

Chemical Name:(2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
CAS No.:119881-39-9
Molecular Formula:C₁₇H₂₅N₃O₅S
Molecular Weight:383.469
Hs Code.:

Synonyms:(2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

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Chemical Property of (2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

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Technology Process of (2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

There total 7 articles about (2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₃₃N₃O₅SSi

: 119881-39-9
(2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Guidance literature:: With ethanol; In 1,4-dioxane; chloroform; at 36 ℃; for 0.166667h;
DOI:10.1021/jm00126a041

Reference yield:

: 1025-55-4
6-aminopenicillanic acid trimethylsilyl ester

: 119881-39-9
(2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dioxane; CHCl₃ / 1.) r.t., 45 min, 2.) 36 deg C, 15 min

2: aq. ethanol / dioxane; CHCl₃ / 0.17 h / 36 °C

With ethanol; In 1,4-dioxane; chloroform;
DOI:10.1021/jm00126a041

Reference yield:

: 100-64-1
cyclohexanone-oxime

: 119881-39-9
(2S,5R,6R)-6-(3-Cyclohexylideneaminooxy-propionylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 41 percent / 2 N ethanolic KOH / ethanol / 48 h / 35 °C

2: 73 percent / KOH / ethanol / 48 h / Ambient temperature

3: triethylamine / CHCl₃; dioxane / 0.5 h / -10 °C

4: dioxane; CHCl₃ / 1.) r.t., 45 min, 2.) 36 deg C, 15 min

5: aq. ethanol / dioxane; CHCl₃ / 0.17 h / 36 °C

With potassium hydroxide; ethanol; triethylamine; In 1,4-dioxane; ethanol; chloroform;
DOI:10.1021/jm00126a041