<5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone

Base Information

• Chemical Name: <5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone
• CAS No.: 129609-21-8
• Molecular Formula: C₂₀H₂₃ClN₄O₂
• Molecular Weight: 386.881

Synonyms:<5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone

Chemical Property of <5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone

Chemical Property:

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Technology Process of <5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone

There total 4 articles about <5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-pyrrolidinocyclopent-1-ene (7148-07-4) + 5-Chloro-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carbonyl chloride (96938-91-9) → <5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone (129609-21-8)

Guidance literature:

With triethylamine; In dichloromethane; at -30 ℃; for 1h;

Reference yield:

1-(azidomethyl)-4-methoxybenzene (70978-37-9) → <5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone (129609-21-8)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium t-butoxide / ethanol

2: phosphorous pentachloride / benzene / 1.5 h / 40 °C

3: saponification according to J_. Heterocyclic Chem_., 22, 77-80 ⁽¹⁹⁸⁵⁾

4: according to J_. Heterocyclic Chem_., 22, 77-80 ⁽¹⁹⁸⁵⁾

5: 74 percent / triethylamine / CH₂Cl₂ / 1 h / -30 °C

With phosphorus pentachloride; potassium tert-butylate; triethylamine; In ethanol; dichloromethane; benzene;

Reference yield:

5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester (75020-41-6) → <5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone (129609-21-8)

Guidance literature:

Multi-step reaction with 4 steps

1: phosphorous pentachloride / benzene / 1.5 h / 40 °C

2: saponification according to J_. Heterocyclic Chem_., 22, 77-80 ⁽¹⁹⁸⁵⁾

3: according to J_. Heterocyclic Chem_., 22, 77-80 ⁽¹⁹⁸⁵⁾

4: 74 percent / triethylamine / CH₂Cl₂ / 1 h / -30 °C

With phosphorus pentachloride; triethylamine; In dichloromethane; benzene;

upstream raw materials:

1-pyrrolidinocyclopent-1-ene

5-Chloro-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carbonyl chloride

1-(azidomethyl)-4-methoxybenzene

5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Downstream raw materials:

<2-(3-Trifluoromethylphenylamino)-1-cyclopenten-1-yl><5-chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl>methanone

3-(4-Methoxyphenylmethyl)-4-(3-trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

3-(4-Methoxyphenylmethyl)-4-(3-chlorophenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

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