70978-37-9

Basic information

• Product Name: 4-Methoxybenzyl azide
• Synonyms: Benzene, 1-(azidomethyl)-4-methoxy-
• CAS NO: 70978-37-9
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.17656
• Mol File: 70978-37-9.mol
• Article Data: 159

Chemical Properties

• Melting Point: 70-71℃
• Boiling Point: 126 °C(Press: 14 Torr)
• Appearance: /
• Density: 1.063 g/cm3 (420 ºC)
• Refractive Index: 1.5272 (589.3 nm 20℃)
• CAS DataBase Reference: 4-Methoxybenzyl azide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxybenzyl azide(70978-37-9)
• EPA Substance Registry System: 4-Methoxybenzyl azide(70978-37-9)

Safety Data

• Hazardous Substances Data: 70978-37-9(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzyl azide is a chemical compound with the molecular formula C8H9N3O. It is an organic compound with a methoxy group (-OCH3) attached to a benzene ring and an azide functional group (-N3). 4-Methoxybenzyl azide is commonly used in organic synthesis as a reagent for the introduction of azide groups into molecules. It is also used in the preparation of pharmaceuticals, agrochemicals, and other organic compounds. 4-Methoxybenzyl azide is known for its potential as a precursor in click chemistry reactions to produce diverse chemical compounds. Additionally, 4-Methoxybenzyl azide plays a crucial role as a building block in the production of compounds used in the pharmaceutical and material science industries.

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 4648-54-8 trimethylsilylazide 
• 2746-25-0 p-Methoxybenzyl bromide 
• 46122-80-9 (4-methoxybenzyl)dimethylsulfonium 
• 105-13-5 4-Methoxybenzyl alcohol 
• 18494-82-1 2-(4-methoxy-benzyloxy)-tetrahydro-pyran 
• 100-66-3 methoxybenzene 
• 104-93-8 p-methylanizole 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 92567-07-2 1-(diazidomethyl)-4-methoxybenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-21-2 p-methoxybenzyl acetate 
• 90673-97-5 methanesulfonic acid 4-methoxybenzyl ester 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 141072-06-2 methyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 130231-84-4 4-(p-methoxybenzyl)-5-picrylimino-1,2,3,4-thiatriazoline 
• 31794-11-3 1-(p-methoxybenzyl)-1,2,3-triazole 
• 110691-29-7 1-(4-methoxybenzyl)-4,4-bis(ethoxycarbonyl)-5-phenylthio-δ²-1,2,3-triazoline 
• 133992-53-7 5-amino-1-[(4-methoxyphenyl)methyl]-1,2,3-triazole-4-carboxamide 
• 81581-05-7 ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 180723-17-5 1-(4-Methoxybenzyl)-1H-1,2,3-triazole-4,5-dicarboxylic acid 
• 3261-60-7 N-(4-methoxybenzylidene)-4-methoxybenzylamine 
• 14371-13-2 4-methoxybenzaldehyde dimethylhydrazone 
• 853017-03-5 {2-[((E)-Hex-2-enyl)oxy]-5,5-dimethyl-2λ⁵-[1,3,2]dioxaphosphinan-2-ylidene}-(4-methoxy-benzyl)-amine 
• 35573-36-5 N-(4-methoxyphenylmethyl)carbamic acid ethyl ester 
• 70875-47-7 1-(4'-methoxyphenylmethyl)azetidin-2-one 
• 97326-40-4 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazolo-4-carboxylic Acid 
• 926659-05-4 12-methyl-5-(4-methoxybenzyl)-3,4,5,12-tetraazatricyclo[6.3.1.02,6]dodeca-2⁽⁶⁾,3-diene 

Relevant articles and documents

Regioselectivity in the 1,3-dipolar cycloaddition reactions of nitrile oxides and organic azides with bromocarbazole-1,4-diones

The effect exerted by the presence of a bromine atom in 2 or 3 position of a carbazole-1,4-dione on the regiocontrol of 1,3-dipolar cycloaddition reactions with nitrile oxides and organic azides was investigated. Comparison with the results obtained with

Dipolar HCP materials as alternatives to DMF solvent for azide-based synthesis

Hypercrosslinked polymers HCP-DMF and HCP-DMF-SO3H containing abundant and flexible DMF moieties were designed and synthesized. Benefitting from the solvation microenvironment provided by the pseudo-DMF moities, the polar HCPs manifested outstanding performances in the conversions of NaN3 to benzylic azides and 1,2,3-triazoles in EtOH (95%), respectively, avoiding the use of risky DMF and improving the separation processes of the products.

Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives

This study focused on synthesis various dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives under the conditions of green chemistry without the use of solvent and catalysts. Their inhibition properties were also investigated on xanthine oxidase (XO) activity. All dimethanol and dicarboxylate derivatives exhibited significant inhibition activities with IC50 values ranging from 0.71 to 2.25 μM. Especially, (1-(3-bromobenzyl)-1H-1,2,3-triazole-4,5-diyl)dimethanol (5c) and dimethyl 1-(4-chlorobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate (6 g) compounds were found to be the most promising derivatives on the XO enzyme inhibition with IC50 values 0.71 and 0.73 μM, respectively. Moreover, the double docking procedure was to evaluate compound modes of inhibition and their interactions with the protein (XO) at atomic level. Surprisingly, the docking results showed a good correlation with IC50 [correlation coefficient (R2 = 0.7455)]. Also, the docking results exhibited that the 5c, 6f and 6 g have lowest docking scores ?4.790, ?4.755, and ?4.730, respectively. These data were in agreement with the IC50 values. These results give promising beginning stages to assist in the improvement of novel and powerful inhibitor against XO.