benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate

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Chemical Name:benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate
CAS No.:906536-21-8
Molecular Formula:C₃₅H₃₈N₄O₅
Molecular Weight:594.711
Hs Code.:

Synonyms:benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate

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Chemical Property of benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate

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Technology Process of benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate

There total 2 articles about benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 906536-20-7
N-(tert-butoxycarbonyl)-D-phenylalanyl-(4R)-N-({[(benzyloxy)carbonyl]amino}ethyl)-4-(2-naphthylmethoxy)-D-prolinamide

: 906536-21-8
benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h;
DOI:10.1021/jm060384p

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 906536-21-8
benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.95 g / 1H-benzotriazole; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 3 h

2: 100 percent / TFA / CH₂Cl₂ / 3 h

With 4-methyl-morpholine; 1,2,3-Benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060384p

Reference yield: 69.0%

: 906536-21-8
benzyl 2-((2R,4R)-1-((R)-2-amino-3-phenylpropanoyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamido)ethylcarbamate

: 35146-32-8,199119-46-5
2-amino-3-(N-tritylimidazolyl)propionic acid

: N-(tert-butoxycarbonyl)-1-trityl-L-histidyl-D-phenylalanyl-(4R)-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-4-(2-naphthylmethoxy)-D-prolinamide

Guidance literature:: With 4-methyl-morpholine; 1,2,3-Benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm060384p