tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

Base Information

Chemical Name:tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate
CAS No.:120230-79-7
Molecular Formula:C₁₉H₂₉NO₅
Molecular Weight:351.443
Hs Code.:

Synonyms:tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

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Chemical Property of tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

Chemical Property:

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Technology Process of tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

There total 3 articles about tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120230-78-6
tert-butyl (2S,3S)-2-<(9-phenylfluorenyl)amino>-3-isopropyl-4-hydroxybutanoate

: 120230-79-7
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, HOAc / 10percent Pd/C / methanol / 760 Torr

2: NaHCO₃ / ethyl acetate; H₂O / 1.5 h / 0 °C

With hydrogen; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In methanol; water; ethyl acetate;
DOI:10.1021/jo00274a037

Reference yield:

: 120230-44-6
2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

: 120230-79-7
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / diisobutylaluminum hydride (DIBAL) / toluene; hexane / 0.33 h / -30 °C

2: H₂, HOAc / 10percent Pd/C / methanol / 760 Torr

3: NaHCO₃ / ethyl acetate; H₂O / 1.5 h / 0 °C

With hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In methanol; hexane; water; ethyl acetate; toluene;
DOI:10.1021/jo00274a037

Reference yield:

: (2S,3S)-2-Amino-3-hydroxymethyl-4-methyl-pentanoic acid tert-butyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 120230-80-0
((3S,4S)-4-Isopropyl-2-oxo-tetrahydro-furan-3-yl)-carbamic acid benzyl ester

: 120230-79-7
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 ℃; for 90h; Yield given. Yields of byproduct given;
DOI:10.1021/jo00274a037