2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

Base Information

Chemical Name:2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester
CAS No.:120230-44-6
Molecular Formula:C₃₁H₃₅NO₄
Molecular Weight:485.623
Hs Code.:

Synonyms:2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

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Chemical Property of 2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

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Technology Process of 2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

There total 1 articles about 2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41029-44-1
isopropyl triflate

: 120230-41-3
N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester

: 120230-44-6
2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

: 120230-45-7
2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

Guidance literature:: With potassium hexamethylsilazane; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, toluene, -78 deg , 45 min, 2.) hexane, -78 deg C, 60 min;
DOI:10.1021/jo00274a037

Reference yield: 78.0%

: 120230-44-6
2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

: 120230-78-6
tert-butyl (2S,3S)-2-<(9-phenylfluorenyl)amino>-3-isopropyl-4-hydroxybutanoate

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -30 ℃; for 0.333333h;
DOI:10.1021/jo00274a037

Reference yield:

: 120230-44-6
2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

: 120230-81-1
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / diisobutylaluminum hydride (DIBAL) / toluene; hexane / 0.33 h / -30 °C

2: H₂, HOAc / 10percent Pd/C / methanol / 760 Torr

3: NaHCO₃ / ethyl acetate; H₂O / 1.5 h / 0 °C

4: 80 percent / N-chlorosuccinimide (NCS), (CH₃)2S / toluene / 4 h / -25 °C

With N-chloro-succinimide; dimethylsulfide; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In methanol; hexane; water; ethyl acetate; toluene;
DOI:10.1021/jo00274a037