t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate

Base Information

• Chemical Name: t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate
• CAS No.: 165529-95-3
• Molecular Formula: C₁₉H₂₆BrNO₆
• Molecular Weight: 444.323
• Mol file: 165529-95-3.mol

Synonyms:t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate

Chemical Property of t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate

There total 2 articles about t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

→ t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate (165529-95-3)

Guidance literature:

Reference yield:

3-bromo-4-methylbenzoic acid tert-butyl ester (160952-57-8) → t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate (165529-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS, (PhCO)2O₂ / CCl₄ / Heating

2: dimethylformamide / 60 °C

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0960-894X(96)00432-5

Reference yield: 95.0%

t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate (165529-95-3) → t-butyl 3-bromo-4-[(t-butoxycarbonyl)amino]methylbenzoate (165529-96-4)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/0960-894X(96)00432-5

upstream raw materials:

3-bromo-4-methylbenzoic acid tert-butyl ester

Downstream raw materials:

t-butyl 3-bromo-4-[(t-butoxycarbonyl)amino]methylbenzoate

methyl (R,S)-3-methoxycarbonyl-4-[5-carboxy-2-(aminomethyl)phenyl]butanoate

methyl (R,S)-7-benzyloxycarbonyl-2,3,4,5-tetrahydro-3-oxo-1H-2-benzazepine-4-acetate

methyl (R,S)-7-benzyloxycarbonyl-2,3,4,5-tetrahydro-2-methyl-3-oxo-1H-2-benzazepine-4-acetate