160952-57-8Relevant articles and documents
Creation of superior carboxyfluorescein dyes by blocking donor-excited photoinduced electron transfer
Mineno, Tomoko,Ueno, Tasuku,Urano, Yasuteru,Kojima, Hirotatsu,Nagano, Tetsuo
, p. 5963 - 5966 (2006)
(Chemical Equation Presented) Carboxyfluoresceins are widely utilized as fluorescence labeling reagents, but we recently found that their emission intensity is markedly decreased after esterification. On the basis of our hypothesis that the fluorescence d
A Fluorescent Probe for Rapid, High-Contrast Visualization of Folate-Receptor-Expressing Tumors In Vivo
Echizen, Honami,Hanaoka, Kenjiro,Ikeno, Takayuki,Komatsu, Toru,Miura, Masayuki,Nagano, Tetsuo,Numasawa, Koji,Saito, Naoko,Ueno, Tasuku,Urano, Yasuteru,Yamaguchi, Yoshifumi,Yasunaga, Masahiro
supporting information, p. 6015 - 6020 (2020/03/04)
Folate receptors (FRs) are membrane proteins involved in folic acid uptake, and the alpha isoform (FR-α) is overexpressed in ovarian and endometrial cancer cells. For fluorescence imaging of FRs in vivo, the near-infrared (NIR) region (650–900 nm), in which tissue penetration is high and autofluorescence is low, is optimal, but existing NIR fluorescent probes targeting FR-α show high non-specific tissue adsorption, and require prolonged washout to visualize tumors. We have designed and synthesized a new NIR fluorescent probe, FolateSiR-1, utilizing a Si-rhodamine fluorophore having a carboxy group at the benzene moiety, coupled to a folate ligand moiety through a negatively charged tripeptide linker. This probe exhibits very low background fluorescence and afforded a tumor-to-background ratio (TBR) of up to 83 in FR-expressing tumor-bearing mice within 30 min. Thus, FolateSiR-1 has the potential to contribute to the research in the field of biology and the clinical medicine.
Silicon and germanium dyes for use in genetic identity
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, (2015/11/16)
Si- and Ge-based dyes and methods of using same.