C₅₄H₇₆O₆Si₂

Base Information

• Chemical Name: C₅₄H₇₆O₆Si₂
• CAS No.: 1338649-20-9
• Molecular Formula: C₅₄H₇₆O₆Si₂
• Molecular Weight: 877.365
• Mol file: 1338649-20-9.mol

Synonyms:C₅₄H₇₆O₆Si₂

Chemical Property of C₅₄H₇₆O₆Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₇₆O₆Si₂

There total 4 articles about C₅₄H₇₆O₆Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-(t-butyldiphenylsilyloxy)-1-(tetrahydro-2H-pyran-2-yloxy)hept-6-ene (1338648-95-5) → C54H76O6Si2 (1338649-20-9)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 20h; Inert atmosphere;

DOI:10.1021/ol202541b

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → C54H76O6Si2 (1338649-20-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 2 h

2.1: iodine; magnesium / tetrahydrofuran / 1.42 h / 20 °C / Inert atmosphere

2.2: -40 - -10 °C / Inert atmosphere

2.3: -40 - 20 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 h / 40 °C / Inert atmosphere

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; iodine; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Grignard reaction / 2.2: Grignard reaction / 2.3: Grignard reaction;

DOI:10.1021/ol202541b

Reference yield:

(2R)-1-(tetrahydro-2H-pyran-2-yloxy)hept-6-en-2-ol (1338648-94-4) → C54H76O6Si2 (1338649-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 h / 40 °C / Inert atmosphere

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol202541b

upstream raw materials:

3,4-dihydro-2H-pyran

(2R)-1-(tetrahydro-2H-pyran-2-yloxy)hept-6-en-2-ol

(2R)-(t-butyldiphenylsilyloxy)-1-(tetrahydro-2H-pyran-2-yloxy)hept-6-ene

2-(((R)-oxiran-2-yl)methoxy)tetrahydro-2H-pyran