[6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

Base Information

Chemical Name:[6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid
CAS No.:1394138-50-1
Molecular Formula:C₂₉H₃₀O₇S
Molecular Weight:522.619
Hs Code.:

Synonyms:[6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

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Chemical Property of [6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

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Technology Process of [6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

There total 10 articles about [6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid methyl ester

: 1394138-50-1
[6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

Guidance literature:: [6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid methyl ester; With water; sodium hydroxide; In dimethyl sulfoxide; at 25 - 70 ℃; for 21h;

With hydrogenchloride; In water; pH=1 - 2;

Reference yield:

: 1372195-69-1
2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene

: 1394138-50-1
[6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / triphenylphosphine; palladium diacetate; tetrabutylammomium bromide / tetrahydrofuran / 8 h / Reflux; Inert atmosphere

2.1: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 25 °C

3.1: potassium phosphate / N,N-dimethyl-formamide / 3 h / 70 °C

4.1: sodium hydroxide; water / dimethyl sulfoxide / 21 h / 25 - 70 °C

4.2: pH 1 - 2

With potassium phosphate; water; sodium hydroxide; trichlorophosphate; tetrabutylammomium bromide; palladium diacetate; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1000413-84-2
2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-carbaldehyde

: 1394138-50-1
[6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water; sodium tetrahydroborate / ethanol / 1 h / 25 °C

2.1: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 25 °C

3.1: potassium phosphate / N,N-dimethyl-formamide / 3 h / 70 °C

4.1: sodium hydroxide; water / dimethyl sulfoxide / 21 h / 25 - 70 °C

4.2: pH 1 - 2

With sodium tetrahydroborate; potassium phosphate; water; sodium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;