2-bromo-1,3-dimethyl-5-(3-(methylsulfonyl)propoxy)benzene

Base Information

• Chemical Name: 2-bromo-1,3-dimethyl-5-(3-(methylsulfonyl)propoxy)benzene
• CAS No.: 1372195-69-1
• Molecular Formula: C₁₂H₁₇BrO₃S
• Molecular Weight: 321.235
• Mol file: 1372195-69-1.mol

Synonyms:2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene

Chemical Property of 2-bromo-1,3-dimethyl-5-(3-(methylsulfonyl)propoxy)benzene

Chemical Property:

• Boiling Point: 482.6±45.0 °C(Predicted)
• Density: 1.380±0.06 g/cm3(Predicted)

Purity/Quality:

99.9% ^*data from raw suppliers

2-Bromo-1,3-dimethyl-5-(3-(methylsulfonyl)propoxy)benzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1,3-dimethyl-5-(3-(methylsulfonyl)propoxy)benzene

There total 6 articles about 2-bromo-1,3-dimethyl-5-(3-(methylsulfonyl)propoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(methylsulfonyl)propyl 4-methylbenzenesulfonate (263400-88-0) + 4-bromo-3,5-dimethylphenol (7463-51-6) → 2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene (1372195-69-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 24h; Inert atmosphere;

Reference yield:

3-(methylthio)-1-propanol (505-10-2) + 4-bromo-3,5-dimethylphenol (7463-51-6) → 2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene (1372195-69-1)

Guidance literature:

3-(methylthio)-1-propanol; 4-bromo-3,5-dimethylphenol; With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In dichloromethane; for 2h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

Reference yield:

(3-(4-bromo-3,5-dimethylphenoxy)propyl)(methyl)sulfane (1000414-12-9) → 2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene (1372195-69-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

upstream raw materials:

3-(methylsulfonyl)propyl 4-methylbenzenesulfonate

4-bromo-3,5-dimethylphenol

3-(methylthio)-1-propanol

(3-(4-bromo-3,5-dimethylphenoxy)propyl)(methyl)sulfane

Downstream raw materials:

2-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane

2-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-((S)-6-((R)-4-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

methyl 2-((S)-6-((R)-4-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate