(4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane

Base Information

• Chemical Name: (4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane
• CAS No.: 168912-28-5
• Molecular Formula: C₂₁H₃₀O₄
• Molecular Weight: 346.467
• Mol file: 168912-28-5.mol

Synonyms:(4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane

Chemical Property of (4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane

There total 1 articles about (4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4R,5R)-4,5-bis(1-hydroxycyclopentyl)-2-phenyl-1,3-dioxolane (168912-27-4) + methyl iodide (74-88-4) → (4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane (168912-28-5)

Guidance literature:

With sodium hydride; In toluene; paraffin; for 24h; Heating;

Reference yield: 75.0%

(4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane (168912-28-5) → C21H30O5 (949594-50-7)

Guidance literature:

With sodium bromate; sodium dithionite; In water; ethyl acetate; for 1h;

DOI:10.1080/00397910701462153

Reference yield:

(4R,5R)-4,5-bis(1-methoxycyclopentyl)-2-phenyl-1,3-dioxolane (168912-28-5) → 3-[(4R,5R)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime (281681-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / H₂ / 10percent Pd/C / methanol / 24 h / 20 °C / 51716.2 Torr

2: 90 percent / aq. HCl / CHCl₃ / 1 h / 20 °C

With hydrogenchloride; hydrogen; 10percent Pd/C; In methanol; chloroform; 1: Hydrogenolysis / 2: Transesterification;

DOI:10.1039/b004573j

upstream raw materials:

(4R,5R)-4,5-bis(1-hydroxycyclopentyl)-2-phenyl-1,3-dioxolane

methyl iodide

Downstream raw materials:

C₂₁H₃₀O₅

3-[(4R,5R)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime

3-[(4R,5R)-4,5-bis(1-methoxycyclopentyl)-1,3,2-dioxaborolan-2-yl]propiophenone