(E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one

Base Information

• Chemical Name: (E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one
• CAS No.: 1245905-86-5
• Molecular Formula: C₁₆H₁₀F₄O
• Molecular Weight: 294.248
• Mol file: 1245905-86-5.mol

Synonyms:(E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one

Chemical Property of (E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one

There total 1 articles about (E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,2,2-Trifluoroacetophenone (434-45-7) + Br(1-)*C26H21FOP(1+) (120302-61-6) → (E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one (1245905-86-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 80 ℃; for 3.25h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00379

Reference yield: 92.0%

(E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one (1245905-86-5) + phenylmagnesium bromide (100-58-3) → biphenyl (92-52-4,1594-86-1) + 4,4-difluoro-1-(4-fluorophenyl)-3-phenylbut-3-en-1-one

Guidance literature:

(E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one; With copper(I) thiophene-2-carboxylate; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.3h; Schlenk technique; Inert atmosphere;

phenylmagnesium bromide; In dichloromethane; at 20 ℃; for 3.16667h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00379

Reference yield:

(E)-1-(4-fluorophenyl)-4,4,4-trifluoro-3-phenylbut-2-en-1-one (1245905-86-5) → 3-(4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-5-phenylisoxazole

Guidance literature:

With hydroxylamine; cetyltrimethylammonim bromide; potassium hydroxide; In water; 1,2-dichloro-ethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201002065

upstream raw materials:

2,2,2-Trifluoroacetophenone

Br^(1-)*C₂₆H₂₁FOP⁽¹⁺⁾

Downstream raw materials:

(R)-3-(4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-5-phenylisoxazole

biphenyl