2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 122252-95-3
• Molecular Formula: C₂₂H₂₀F₂N₂O₂
• Molecular Weight: 382.41

Synonyms:2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester

There total 2 articles about 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester (123837-56-9) → 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester (122252-95-3)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; at 50 ℃; for 3h; Yield given;

DOI:10.1021/jm00163a010

Reference yield:

4-fluorobenzamidine hydrochloride (456-14-4) → 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester (122252-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: KOAc / toluene / 24 h / Heating

2: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / toluene / 3 h / 50 °C

With potassium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene;

DOI:10.1021/jm00163a010

Reference yield:

2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester (122252-95-3) → [2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol (122253-18-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1021/jm00163a010

upstream raw materials:

2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

4-fluorobenzamidine hydrochloride

Downstream raw materials:

[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol

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