456-14-4

Basic information

• Product Name: 4-Fluorobenzamidine hydrochloride
• Synonyms: 4-FLUORO-BENZAMIDINE HYDROCHLORIDE;4-FLUOROBENZAMIDINE HCL;4-fluorobenzimidamide hydrochloride;4-Fluoro-benzamidine hydrochloride ,95%;4-fluorobenzene-1-carboxiMidaMide hydrochloride;4-FluorobenzaMidine hydrochloride/2339-59-5;4-Fluorobenzamidine Hydrochloride Hydrate
• CAS NO: 456-14-4
• Molecular Formula: C₇H₇FN₂*ClH
• Molecular Weight: 174.6
• Product Categories: pharmacetical
• Mol File: 456-14-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 209.0 to 213.0 °C
• Boiling Point: 243.6 °C at 760 mmHg
• Flash Point: 101.1 °C
• Appearance: /Solid
• Vapor Pressure: 0.0255mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-Fluorobenzamidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorobenzamidine hydrochloride(456-14-4)
• EPA Substance Registry System: 4-Fluorobenzamidine hydrochloride(456-14-4)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 456-14-4(Hazardous Substances Data)

Usage

Uses

4-Fluorobenzamidine hydrochloride is used as pharmaceutical intermediate.

InChI:InChI=1/C7H7FN2.ClH/c8-6-3-1-5(2-4-6)7(9)10;/h1-4H,(H3,9,10);1H

Upstream product

• 56108-05-5 4-fluorobenzamidic acid methylester hydrochloride salt 
• 4278-01-7 ethyl 4-(fluorophenyl)carboximidate hydrochloride 
• 22179-78-8 4-fluoro-benzamidoxime 

Downstream Products

• 76128-69-3 2-(4-fluoro-phenyl)-4-phenyl-pyrimidine 
• 944904-93-2 2-(4-fluorophenyl)pyrimidine-5-carbaldehyde 
• 1038410-94-4 3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole 
• 1613637-81-2 2,4-bis(4-fluorophenyl)-1,3,5-triazine 
• 157141-82-7 2,4-bis(p-fluorophenyl)-6-phenyl-1,3,5-triazine 
• 1208259-07-7 2-(4-fluorophenyl)-quinazoline 

Relevant articles and documents

Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates

Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)2-catalyzed reaction between two amidines using NaHCO3 as a base, 1,10-phenanthroline as an additive and K3[Fe(CN)6]/ atmospheric oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4- triazoles with yields up to 64% rests on the Cu(OTf)2-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step.

Pyrimidine derivatives and liquid crystal compositions including same

2-phenyl-5-(4'-trans-cyclohexyl) phenyl pyrimidine derivatives represented by the general formula: STR1 wherein R is a straight chain alkyl group having 1 to 10 carbon atoms; X is CN or F; Y is F or H; Z is F or H; and when X is F, at least one of Y and Z is H; and the cyclohexane ring is a trans isomer, exhibiting a nematic phase and having a high nematic phase-isotropic liquid phase transition temperature (N-I Point) and large positive dielectric constant anisotropy (Δε). The pyrimidine derivatives may be included in liquid crystal compositions for improved display devices having a wide temperature range, including a high N-I point, a low threshold voltage and a low driving voltage.