4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde

Base Information

Chemical Name:4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde
CAS No.:107223-34-7
Molecular Formula:C₁₈H₁₇NO₃
Molecular Weight:295.338
Hs Code.:

Synonyms:4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde

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Chemical Property of 4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde

Chemical Property:

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Technology Process of 4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde

There total 11 articles about 4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 107223-34-7
4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1: 2.) H₂ / 2.) 5percent Pd/C / 1.) water, EtOH, 40 deg C, 4 h, 2.) water, EtOH, 60 psi, 16 h

2: 1.) n-BuLi / 1.) hexane, THF, 4 h, 2.) hexane, THF, 25 deg C, 20 h

3: 77 percent / HOAc, 48percent aq. HBr / 24 h / Heating

4: triethylamine / CH₂Cl₂ / 16 h

5: 1.) NaOEt, 2.) NaI / 1.) EtOH, 0.25 h, 0 deg C, 2.) EtOH, RT, 48 h

6: NH₄OH / ethanol / 4 h

7: 86 percent / H₂O / 24 h / Heating

8: 97 percent / pyridine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h

9: ethyl chloroformate / toluene / 16 h / Ambient temperature

10: 1.) 2-nitropropane Na salt, 2.) dimethylamine / 1.) EtOH, reflux, 4 h, 2.) MeCN, 48 h

With pyridine; dmap; ammonium hydroxide; n-butyllithium; hydrogen bromide; hydrogen; sodium ethanolate; chloroformic acid ethyl ester; sodium 2-nitropropane; acetic acid; dimethyl amine; triethylamine; sodium iodide; palladium on activated charcoal; In ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm00388a028

Reference yield:

: 15184-99-3
N,N-dimethyl-3-methoxybenzylamine

: 107223-34-7
4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) n-BuLi / 1.) hexane, THF, 4 h, 2.) hexane, THF, 25 deg C, 20 h

2: 77 percent / HOAc, 48percent aq. HBr / 24 h / Heating

3: triethylamine / CH₂Cl₂ / 16 h

4: 1.) NaOEt, 2.) NaI / 1.) EtOH, 0.25 h, 0 deg C, 2.) EtOH, RT, 48 h

5: NH₄OH / ethanol / 4 h

6: 86 percent / H₂O / 24 h / Heating

7: 97 percent / pyridine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h

8: ethyl chloroformate / toluene / 16 h / Ambient temperature

9: 1.) 2-nitropropane Na salt, 2.) dimethylamine / 1.) EtOH, reflux, 4 h, 2.) MeCN, 48 h

With pyridine; dmap; ammonium hydroxide; n-butyllithium; hydrogen bromide; sodium ethanolate; chloroformic acid ethyl ester; sodium 2-nitropropane; acetic acid; dimethyl amine; triethylamine; sodium iodide; In ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm00388a028

Reference yield:

: 767-00-0
4-cyanophenol

: 107223-34-7
4-<(4-cyanophenoxy)methyl>-2-hydroxy-3-propylbenzaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaOEt, 2.) NaI / 1.) EtOH, 0.25 h, 0 deg C, 2.) EtOH, RT, 48 h

2: NH₄OH / ethanol / 4 h

3: 86 percent / H₂O / 24 h / Heating

4: 97 percent / pyridine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h

5: ethyl chloroformate / toluene / 16 h / Ambient temperature

6: 1.) 2-nitropropane Na salt, 2.) dimethylamine / 1.) EtOH, reflux, 4 h, 2.) MeCN, 48 h

With pyridine; dmap; ammonium hydroxide; sodium ethanolate; chloroformic acid ethyl ester; sodium 2-nitropropane; dimethyl amine; sodium iodide; In ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm00388a028