C₁₂H₁₆NO₃P

Base Information Edit

Chemical Name:C₁₂H₁₆NO₃P
CAS No.:1616557-93-7
Molecular Formula:C₁₂H₁₆NO₃P
Molecular Weight:253.238
Hs Code.:
Mol file:1616557-93-7.mol

C<sub>12</sub>H<sub>16</sub>NO<sub>3</sub>P

Synonyms:C₁₂H₁₆NO₃P

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Chemical Property of C₁₂H₁₆NO₃P Edit

Chemical Property:

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Technology Process of C₁₂H₁₆NO₃P

There total 11 articles about C₁₂H₁₆NO₃P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20677-12-7
diethyl (4-bromophenyl)phosphonate

: 1616557-93-7
C₁₂H₁₆NO₃P

Guidance literature:: Multi-step reaction with 10 steps

1.1: trimethylsilyl bromide

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

3.1: tetrahydrofuran / -78 °C

4.1: water / 90 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / toluene / Reflux

5.2: Reflux

6.1: triethylamine / dichloromethane

7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 80 °C

8.1: ozone / methanol / -78 °C

9.1: potassium permanganate / acetone

10.1: hydrogenchloride / Reflux

With hydrogenchloride; potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; trimethylsilyl bromide; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; ozone; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetone; toluene; 7.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1616557-93-7
C₁₂H₁₆NO₃P

Guidance literature:: Multi-step reaction with 11 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; potassium acetate / tetrahydrofuran / 22 h / 68 °C

2.1: trimethylsilyl bromide

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

4.1: tetrahydrofuran / -78 °C

5.1: water / 90 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / toluene / Reflux

6.2: Reflux

7.1: triethylamine / dichloromethane

8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 80 °C

9.1: ozone / methanol / -78 °C

10.1: potassium permanganate / acetone

11.1: hydrogenchloride / Reflux

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; trimethylsilyl bromide; carbonochloridic acid 1-chloro-ethyl ester; potassium acetate; potassium carbonate; ozone; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetone; toluene; 8.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

: 4648-58-2
(4-Bromophenyl)phosphonsaeure-dichlorid

: 1616557-93-7
C₁₂H₁₆NO₃P

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / -78 °C

2.1: water / 90 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / toluene / Reflux

3.2: Reflux

4.1: triethylamine / dichloromethane

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 80 °C

6.1: ozone / methanol / -78 °C

7.1: potassium permanganate / acetone

8.1: hydrogenchloride / Reflux

With hydrogenchloride; potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; ozone; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetone; toluene; 5.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.036