6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

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Chemical Name:6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine
CAS No.:145745-02-4
Molecular Formula:C₄₉H₄₁N₃O₇
Molecular Weight:783.88
Hs Code.:

Synonyms:6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

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Chemical Property of 6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

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Technology Process of 6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

There total 9 articles about 6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.4%

: 145745-01-3
6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

: 145745-02-4
6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 36h; Ambient temperature;
DOI:10.1021/jo00054a024

Reference yield: 41.4%

: 1486-51-7
p-(benzyloxy)benzoic acid

: 145745-00-2
5-(4-(Benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

: 145745-02-4
6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

: 145745-01-3
6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

: 6-(4-Benzyloxy-benzoyl)-7-[2-(4-benzyloxy-benzoyl)-4,6-dimethoxy-benzyl]-1,3-bis-benzyloxymethyl-5-(4-benzyloxy-phenyl)-1,7-dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione

Guidance literature:: With trifluoroacetic anhydride; In dichloromethane; at 25 ℃; for 45h; Product distribution;
DOI:10.1021/jo00054a024

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 145745-02-4
6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1: 1) LiH / 1) DMF, 0 deg C, 30 min., 2) r.t., 5 h

2: 1) NaOH, 2) Na₂CO₃ / 1) H₂O, reflux, 1 h, 2) EtOH, reflux, 13.5 h

3: 1) 70 deg C, 2 h, 2) reflux, 45 min.

4: 84.6 percent / Na₂CO₃*H₂O / methanol / 0.08 h / Heating

5: 99 percent / 2,4,6-collidine / CH₂Cl₂ / 0.25 h / -78 °C

6: 76.2 percent / ZnCl₂, tri(2-furyl)phosphine / Pd₂dba3 / various solvent(s) / 24 h / 55 °C

7: 1) trifluoroacetic anhydride (TFAA), 2) CF₃COOH / 1) CH₂Cl₂, r.t., 10 min., 2) r.t., 36 h

With 2,4,6-trimethyl-pyridine; sodium hydroxide; trifuran-2-yl-phosphane; lithium hydride; sodium carbonate; trifluoroacetic acid; trifluoroacetic anhydride; zinc(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane;
DOI:10.1021/jo00054a024