(R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester

Base Information

• Chemical Name: (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester
• CAS No.: 178246-88-3
• Molecular Formula: C₂₃H₃₈O₅Si
• Molecular Weight: 422.637

Synonyms:(R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester

Chemical Property of (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester

There total 5 articles about (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

benzyl (-)-3-hydroxypentanoate (97189-64-5) + (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (178246-87-2) → (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester (178246-88-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 96h;

DOI:10.1002/hlca.19960790311

Reference yield:

(3R)-3-hydroxypentanoic acid (53538-53-7) → (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester (178246-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂

2: 71 percent / 4-dimethylaminopyridine, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 96 h / 0 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/hlca.19960790311

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester (178246-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂

2: 71 percent / 4-dimethylaminopyridine, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 96 h / 0 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/hlca.19960790311

upstream raw materials:

benzyl (-)-3-hydroxypentanoate

(R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid

(3R)-3-hydroxypentanoic acid

tert-butyldimethylsilyl chloride

Downstream raw materials:

(R)-3-((R)-3-Benzyloxy-butyryloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester

(R)-3-Hydroxy-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 178246-88-3 (R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanoic acid (R)-1-benzyloxycarbonylmethyl-propyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send