4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone

Base Information

• Chemical Name: 4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone
• CAS No.: 1089281-10-6
• Molecular Formula: C₁₆H₂₂N₄O₄
• Molecular Weight: 334.375
• Mol file: 1089281-10-6.mol

Synonyms:4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone

Chemical Property of 4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone

There total 1 articles about 4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-Ketopiperazine (5625-67-2) + 1-(3-methoxy-4 nitrophenyl)piperidin-4-one (761440-64-6) → 4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone (1089281-10-6)

Guidance literature:

2-Ketopiperazine; 1-(3-methoxy-4 nitrophenyl)piperidin-4-one; With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In toluene; acetonitrile;

With sodium hydroxide; In methanol; water; toluene; acetonitrile; for 0.166667h;

Reference yield: 76.0%

1-fluoro-2-iodoethane (762-51-6) + 4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone (1089281-10-6) → 1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone (1089281-11-7)

Guidance literature:

4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.75h;

1-fluoro-2-iodoethane; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2-Ketopiperazine

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

Downstream raw materials:

1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}-2-piperazinone