1-Fluoro-2-iodoethane

Base Information

• Chemical Name: 1-Fluoro-2-iodoethane
• CAS No.: 762-51-6
• Molecular Formula: C2H4 F I
• Molecular Weight: 173.957
• Hs Code.: 29033990
• European Community (EC) Number: 691-351-4
• DSSTox Substance ID: DTXSID80227056
• Nikkaji Number: J43.003J
• Wikidata: Q72473616
• Mol file: 762-51-6.mol

Synonyms:1-Fluoro-2-iodoethane;762-51-6;Ethane, 1-fluoro-2-iodo-;1-fluoro-2-iodo-ethane;2-Fluoroethyl iodide;C2H4FI;1-Fluor-2-jodethan [Czech];1-Fluor-2-jodethan;1-iodo-2-fluoroethane;BRN 1730862;MFCD00748131;4-01-00-00165 (Beilstein Handbook Reference);2-fluoro-1-iodoethane;1-Fluoro-2-iodoethane, contains up to 1% copper powder as stabilizer;2-iodo-1-fluoroethane;1-fluoro-2-ethyl iodide;SCHEMBL126270;C2-H4-F-I;DTXSID80227056;AKOS006227793;AS-31130;LS-65569;SY024380;1-Fluoro-2-iodoethane, stabilized over Cu;AM20100746;F1190;FT-0607774;EN300-316786

Chemical Property of 1-Fluoro-2-iodoethane

Chemical Property:

• Vapor Pressure: 44mmHg at 25°C
• Boiling Point: 98-102°C
• Flash Point: 16.2°C
• PSA: 0.00000
• Density: 2.026g/cm³
• LogP: 1.39090
• Storage Temp.: Keep Cold
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 173.93418
• Heavy Atom Count: 4
• Complexity: 10

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Fluoro-2-iodoethane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 20/21/22
• Safety Statements: 23-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CI)F
• Uses: 1-Fluoro-2-iodoethane is used as a reagent in organic synthesis of several compounds including that of fluorinated U-50488 analogs for PET studies of kappa opioid receptors. It is also used in the synthesis of MK-3168, an imidazole analog which acts as a PET tracer for the imaging of brain fatty acid amide hydrolase.

Technology Process of 1-Fluoro-2-iodoethane

There total 5 articles about 1-Fluoro-2-iodoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

Iodoethanol (624-76-0) → 1-fluoro-2-iodoethane (762-51-6)

Guidance literature:

With diethylamino-sulfur trifluoride; In various solvent(s); at 0 ℃; for 2h;

DOI:10.1021/jm00167a031

Reference yield: 15.0%

→ 1-fluoro-2-iodoethane (762-51-6)

Guidance literature:

In methanol; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

1,2-Diiodoethane (624-73-7) → 1-fluoro-2-iodoethane (762-51-6)

Guidance literature:

With mercury(II) fluoride;

upstream raw materials:

2-fluoroethyl bromide

1,2-Diiodoethane

ethene

Iodoethanol

Downstream raw materials:

[3-(2-fluoroethoxymethyl)-5-methoxyphenyl]methanol

2-(3-aminomethyl-1-(2-fluoro-ethyl)-azetidin-3-yl)-8-(2-fluoro-phenyl)-4,5-dihydro-1H-pyrrolo[2,3-f]isoquinoline-3-carboxylic acid lactam

2-(2,3-Difluoro-phenyl)-5-{6-[4-(2-fluoro-ethoxy)-2-trifluoromethyl-phenyl]-pyridazin-3-ylmethyl}-5H-imidazo[4,5-d]pyridazine

1,5-anhydro-4,6-O-benzilidine-2-deoxy-2-[(N-3-benzyloxymethyl)thymin-1-yl]-3-O-(2-fluoroethyl)-D-altrohexitol

Refernces

• 1、 Chesis,Hwang,Welch. "N-(3-[18F]fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography.". . p. 1482 - 1490. Retrieved 2007/10/02.