4-(4-quinolin-3-ylindazol-1-yl)benzonitrile

Base Information

• Chemical Name: 4-(4-quinolin-3-ylindazol-1-yl)benzonitrile
• CAS No.: 1246307-61-8
• Molecular Formula: C₂₃H₁₄N₄
• Molecular Weight: 346.391
• Mol file: 1246307-61-8.mol

Synonyms:4-(4-quinolin-3-ylindazol-1-yl)benzonitrile

Chemical Property of 4-(4-quinolin-3-ylindazol-1-yl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-quinolin-3-ylindazol-1-yl)benzonitrile

There total 4 articles about 4-(4-quinolin-3-ylindazol-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-(4-quinolin-3-ylindazol-1-yl)benzonitrile (1246307-59-4) + trans-4-aminocyclohexan-1-ol (27489-62-9) → 4-(4-quinolin-3-ylindazol-1-yl)benzonitrile (1246307-61-8) + 2-(trans-4-hydroxycyclohexylamino)-4-(4-quinolin-3-ylindazol-1-yl)benzonitrile

Guidance literature:

With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 95 ℃; for 4h; Inert atmosphere;

Reference yield:

4-hydroxyindazole (81382-45-8) → 4-(4-quinolin-3-ylindazol-1-yl)benzonitrile (1246307-61-8)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1.25 h / 95 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; Petroleum ether / 2.5 h / 20 °C / Inert atmosphere

4: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 95 °C / Inert atmosphere

With sodium hydride; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; Petroleum ether;

Reference yield:

trifluoromethanesulphonic acid 1H-indazol-4-yl ester (1246307-56-1) → 4-(4-quinolin-3-ylindazol-1-yl)benzonitrile (1246307-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1.25 h / 95 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; Petroleum ether / 2.5 h / 20 °C / Inert atmosphere

3: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 95 °C / Inert atmosphere

With sodium hydride; sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; Petroleum ether;

upstream raw materials:

2-bromo-4-(4-quinolin-3-ylindazol-1-yl)benzonitrile

trans-4-aminocyclohexan-1-ol

4-hydroxyindazole

trifluoromethanesulphonic acid 1H-indazol-4-yl ester

Downstream raw materials:

4-(4-quinolin-3-ylindazol-1-yl)benzamide