4-HYDROXYINDAZOLE

Base Information

• Chemical Name: 4-HYDROXYINDAZOLE
• CAS No.: 81382-45-8
• Molecular Formula: C7H6N2O
• Molecular Weight: 134.137
• Hs Code.: 29339900
• Mol file: 81382-45-8.mol

Synonyms:4-Hydroxyindazole;

Chemical Property of 4-HYDROXYINDAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 177-178℃
• Refractive Index: 1.76
• Boiling Point: 366.518 °C at 760 mmHg
• PKA: 8.76±0.40(Predicted)
• Flash Point: 175.464 °C
• PSA: 48.91000
• Density: 1.434 g/cm³
• LogP: 1.26850
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxyindazole ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXYINDAZOLE

There total 6 articles about 4-HYDROXYINDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-aminoindazole (41748-71-4) → 4-hydroxyindazole (81382-45-8)

Guidance literature:

4-aminoindazole; With sulfuric acid; water; at 180 ℃;

With sodium hydroxide; In water;

Reference yield: 47.0%

3-(acetylamino)-2-methylphenyl acetate (76064-16-9) → 4-hydroxyindazole (81382-45-8)

Guidance literature:

3-(acetylamino)-2-methylphenyl acetate; With tetrabutylammomium bromide; acetic anhydride; isopentyl nitrite; In ethyl acetate; for 7h; Heating / reflux;

With sodium hydroxide; In methanol; water; at 20 ℃; for 1h;

Reference yield:

5-bromo-1,5,6,7-tetrahydro-4H-indazol-4-one (1031440-14-8,1235325-49-1) → 4-hydroxyindazole (81382-45-8)

Guidance literature:

5-bromo-6,7-dihydro-1H-indazol-4(5H)-one; With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In water; ethyl acetate;

upstream raw materials:

4-aminoindazole

nitro-4 indazole

3-(acetylamino)-2-methylphenyl acetate

5-bromo-1,5,6,7-tetrahydro-4H-indazol-4-one

Downstream raw materials:

4-(2-fluoro-4-nitrophenoxy)-1H-indazole

4-(4-quinolin-3-ylindazol-1-yl)benzamide

4-(4-quinolin-3-ylindazol-1-yl)benzonitrile

2-bromo-4-(4-quinolin-3-ylindazol-2-yl)benzonitrile