5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

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Chemical Name:5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide
CAS No.:1354787-22-6
Molecular Formula:C₃₈H₃₁ClF₄N₆O₈S₂
Molecular Weight:875.278
Hs Code.:

5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

Synonyms:5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

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Chemical Property of 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

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Technology Process of 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

There total 7 articles about 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1235406-57-1
5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354787-23-7
3-(3-Nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-ol

: 1354787-22-6
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

Reference yield:

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1354787-22-6
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2: acetic acid; N-iodo-succinimide / 0 - 20 °C

3: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

4: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

With potassium fluoride; N-iodo-succinimide; sodium hydrogencarbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; 1: Suzuki Coupling / 3: Suzuki Coupling;

Reference yield:

: 191724-12-6
3'-(trifluoromethyl)[1,1'-biphenyl]-4-ol

: 1354787-22-6
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; N-iodo-succinimide / 0 - 20 °C

2: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

With potassium fluoride; N-iodo-succinimide; potassium carbonate; acetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; dimethyl sulfoxide; 2: Suzuki Coupling;