4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Name:4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
CAS No.:1354786-33-6
Molecular Formula:C₂₄H₁₅ClF₄N₆O₃S₂
Molecular Weight:611
Hs Code.:

Synonyms:4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Property of 4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Technology Process of 4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

There total 6 articles about 4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1354787-22-6
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide

: 1354786-33-6
4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(1,3,4-thiadiazol-2-yl)benzene sulfonamide; With sodium dithionite; potassium carbonate; In water; acetonitrile; at 40 ℃; for 3h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 540-38-5
p-Iodophenol

: 1354786-33-6
4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2.1: acetic acid; N-iodo-succinimide / 0 - 20 °C

3.1: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

4.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

5.1: potassium carbonate; sodium dithionite / acetonitrile; water / 3 h / 40 °C

5.2: 18 h / 20 °C

With potassium fluoride; N-iodo-succinimide; sodium dithionite; sodium hydrogencarbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 1.1: Suzuki Coupling / 3.1: Suzuki Coupling;

Reference yield:

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1354786-33-6
4-{[3-(3-Amino-1H-pyrazol-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-5-chloro-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2.1: acetic acid; N-iodo-succinimide / 0 - 20 °C

3.1: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

4.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

5.1: potassium carbonate; sodium dithionite / acetonitrile; water / 3 h / 40 °C

5.2: 18 h / 20 °C

With potassium fluoride; N-iodo-succinimide; sodium dithionite; sodium hydrogencarbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 1.1: Suzuki Coupling / 3.1: Suzuki Coupling;