di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

Base Information

Chemical Name:di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate
CAS No.:741292-52-4
Molecular Formula:C₂₇H₄₄FO₄P
Molecular Weight:482.616
Hs Code.:

Synonyms:di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

Chemical Property:

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Technology Process of di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

There total 7 articles about di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 741292-50-2
di-(1R,2S,5R)-menthyl 2-fluorobenzoylphosphonate

: 741292-52-4
di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

Guidance literature:: With sodium tetrahydroborate; In ethanol;
DOI:10.1002/hc.20391

Reference yield:

: 741292-50-2
di-(1R,2S,5R)-menthyl 2-fluorobenzoylphosphonate

: 889103-62-2
di-(1R,2S,5R)-menthyl (S)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

: 741292-52-4
di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

Guidance literature:: With sodium tetrahydroborate; L-Tartaric acid; In tetrahydrofuran; at -30 ℃; Title compound not separated from byproducts;
DOI:10.1016/j.tetasy.2006.03.025

Reference yield:

: 889103-64-4
di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate

: 741292-52-4
di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / pyridinium dichromate; trimethylchlorosilane / CH₂Cl₂ / 20 °C

2: sodium borohydride; (R,R)-(+)-tartaric acid / tetrahydrofuran / 24 h / -30 °C

With sodium tetrahydroborate; dipyridinium dichromate; chloro-trimethyl-silane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2007.04.101