di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate

Base Information

• Chemical Name: di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate
• CAS No.: 889103-64-4
• Molecular Formula: C₂₇H₄₄FO₄P
• Molecular Weight: 482.616
• Mol file: 889103-64-4.mol

Synonyms:di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate

Chemical Property of di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate

There total 2 articles about di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Fluorobenzaldehyde (446-52-6) + hydrogen di[(1R,2S,5R)-menthyl] phosphite (211183-18-5) → di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate (889103-64-4)

Guidance literature:

DOI:10.1007/s11176-005-0386-8

Reference yield: 97.0%

di-(1R,2S,5R)-menthyl 2-fluorobenzoylphosphonate (741292-50-2) → di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate (889103-64-4)

Guidance literature:

With sodium tetrahydroborate; L-Tartaric acid; In tetrahydrofuran; at -30 ℃;

DOI:10.1007/s11176-005-0386-8

Reference yield: 95.0%

di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(2-fluorophenyl)methylphosphonate (889103-64-4) → di-(1R,2S,5R)-menthyl 2-fluorobenzoylphosphonate (741292-50-2)

Guidance literature:

With dipyridinium dichromate; chloro-trimethyl-silane; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2007.04.101

upstream raw materials:

di-(1R,2S,5R)-menthyl 2-fluorobenzoylphosphonate

2-Fluorobenzaldehyde

hydrogen di[(1R,2S,5R)-menthyl] phosphite

Downstream raw materials:

di-(1R,2S,5R)-menthyl 2-fluorobenzoylphosphonate

di-(1R,2S,5R)-menthyl (S)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate

di-(1R,2S,5R)-menthyl (R)-1-(2-fluorophenyl)-1-hydroxymethylphosphonate