7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:1361570-22-0
Molecular Formula:C₂₁H₁₃F₄N₇O₂
Molecular Weight:471.374
Hs Code.:

Synonyms:7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

There total 3 articles about 7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1361570-97-9
4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N-(2,2,2-trifluoroethyl)pyrimidine-5-carboxamide

: 530-62-1
1,1'-carbonyldiimidazole

: 1361570-22-0
7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: 4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N-(2,2,2-trifluoroethyl)pyrimidine-5-carboxamide; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Cooling with ice;

1,1'-carbonyldiimidazole; In tetrahydrofuran; mineral oil; for 2.5h; Cooling with ice; Reflux;

Reference yield:

: 304874-07-5
ethyl 4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-5-carboxylate

: 1361570-22-0
7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / 1,4-dioxane / 4 h / 60 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Cooling with ice

3.2: 2.5 h / Cooling with ice; Reflux

With water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1361570-96-8
4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-5-carboxylic acid

: 1361570-22-0
7-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-3-(2,2,2-trifluoroethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Cooling with ice

2.2: 2.5 h / Cooling with ice; Reflux

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;