304874-07-5Relevant articles and documents
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.
Straub, Alexander,Benet-Buckholz, Jordi,Froede, Rita,Kern, Armin,Kohlsdorfer, Christian,Schmitt, Peter,Schwarz, Thomas,Siefert, Hans Martin,Stasch, Johannes Peter
, p. 1711 - 1717 (2007/10/03)
The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543.