N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Base Information

Chemical Name:N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide
CAS No.:1374137-87-7
Molecular Formula:C₃₄H₄₅FN₄O₆S
Molecular Weight:656.819
Hs Code.:

Synonyms:N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Chemical Property of N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Technology Process of N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

There total 18 articles about N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-10-9
N-[(5S)-2-fluoro-6-hydroxy-5-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

: 1374137-87-7
N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: With hydrogen; 20% palladium hydroxide-activated charcoal; In ethanol; ethyl acetate; for 3h; under 760.051 Torr;

Reference yield:

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 1374137-87-7
N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 17 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: lithium borohydride / tetrahydrofuran / 2 h / 0 - 50 °C

2.2: 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 0 - 20 °C

4.1: sodium bromate; ruthenium(IV) oxide hydrate / ethyl acetate; water / 20 - 55 °C

5.1: water; sodium tetrahydroborate / isopropyl alcohol / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

7.1: acetic acid / methanol / 0.5 h / 20 °C

7.2: 20 °C

8.1: sodium hydrogencarbonate / chloroform; water / 1 h / 20 °C

9.1: 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve

9.2: 3 h / 20 °C

10.1: N-fluorobis(benzenesulfon)imide; 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt / isopropyl alcohol; tetrahydrofuran / 24 h / -20 °C

11.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

12.1: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 0 °C

13.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

14.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

15.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

16.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

17.1: hydrogen / 20% palladium hydroxide-activated charcoal / ethyl acetate; ethanol / 3 h / 760.05 Torr

With 1H-imidazole; hydrogenchloride; sodium bromate; sodium tetrahydroborate; lithium borohydride; ruthenium(IV) oxide hydrate; 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt; tetrabutyl ammonium fluoride; water; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 4-methylmorpholine N-oxide; N-fluorobis(benzenesulfon)imide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 590-86-3
isovaleraldehyde

: 1374137-87-7
N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C

1.2: 20 °C

2.1: sodium hydrogencarbonate / chloroform; water / 1 h / 20 °C

3.1: 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve

3.2: 3 h / 20 °C

4.1: N-fluorobis(benzenesulfon)imide; 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt / isopropyl alcohol; tetrahydrofuran / 24 h / -20 °C

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

6.1: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 0 °C

7.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

11.1: hydrogen / 20% palladium hydroxide-activated charcoal / ethyl acetate; ethanol / 3 h / 760.05 Torr

With 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 4-methylmorpholine N-oxide; N-fluorobis(benzenesulfon)imide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;