N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Base Information

Chemical Name:N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide
CAS No.:1374138-12-1
Molecular Formula:C₃₄H₄₅FN₄O₆S
Molecular Weight:656.819
Hs Code.:

Synonyms:N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Chemical Property of N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Technology Process of N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

There total 19 articles about N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374137-87-7
N-[(5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

: 1374138-11-0
N-[(2R,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

: 1374138-12-1
N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: With AD-H; In carbon dioxide; isopropyl alcohol; at 40 ℃; under 75007.5 Torr;

Reference yield:

: 1374138-02-9
benzyl [(2S)-1-{[tert-butyl(diphenyl)silyl]oxy}-6-hydroxyhexan-2-yl](3-methylbutyl)carbamate

: 1374138-11-0
N-[(2R,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

: 1374138-12-1
N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve

1.2: 3 h / 20 °C

2.1: N-fluorobis(benzenesulfon)imide; 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt / isopropyl alcohol; tetrahydrofuran / 24 h / -20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 0 °C

5.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

9.1: hydrogen / 20% palladium hydroxide-activated charcoal / ethyl acetate; ethanol / 3 h / 760.05 Torr

10.1: AD-H / isopropyl alcohol; carbon dioxide / 40 °C / 75007.5 Torr

With 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; N-fluorobis(benzenesulfon)imide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 1374138-03-0
benzyl [(2S)-1-{[tert-butyl(diphenyl)silyl]oxy}-6-oxohexan-2-yl](3-methylbutyl)carbamate

: 1374138-11-0
N-[(2R,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

: 1374138-12-1
N-[(2S,5S)-5-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-2-fluoro-6-hydroxy-hexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-fluorobis(benzenesulfon)imide; 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt / isopropyl alcohol; tetrahydrofuran / 24 h / -20 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 0 °C

4: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

8: hydrogen / 20% palladium hydroxide-activated charcoal / ethyl acetate; ethanol / 3 h / 760.05 Torr

9: AD-H / isopropyl alcohol; carbon dioxide / 40 °C / 75007.5 Torr

With 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; N-fluorobis(benzenesulfon)imide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;