1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene

Base Information

• Chemical Name: 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene
• CAS No.: 381211-85-4
• Molecular Formula: C₃₃H₅₈O₃Si₂
• Molecular Weight: 558.993
• Mol file: 381211-85-4.mol

Synonyms:1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene

Chemical Property of 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene

There total 1 articles about 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxypregna-5,7,16-triene (210219-09-3) → 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene (381211-85-4)

Guidance literature:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxypregna-5,7,16-triene; In tetrahydrofuran; at 18 ℃; for 10h; UV-irradiation;

In tetrahydrofuran; for 3h; Further stages.; Heating;

DOI:10.1016/j.bmcl.2006.03.014

Reference yield:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene (381211-85-4) + N-tert-butyl-2-bromoacetamide (57120-58-8) → C39H69NO4Si2

Guidance literature:

With 15-crown-5; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 5.25h; Heating;

DOI:10.1016/j.bmcl.2006.03.014

Reference yield:

1-ethyl-1-methylpropyl acrylate (336609-22-4) + 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene (381211-85-4) → 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-{2-(1-ethyl-1-methylpropoxycarbonyl)ethoxy}-9,10-secopregna-5,7,10(19),16-tetraene

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 5 ℃; for 18h;

upstream raw materials:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxypregna-5,7,16-triene

Downstream raw materials:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(tert-butoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene