1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

Base Information

Chemical Name:1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene
CAS No.:381213-03-2
Molecular Formula:C₃₈H₆₆O₅Si₂
Molecular Weight:659.11
Hs Code.:

Synonyms:1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

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Chemical Property of 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

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Technology Process of 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

There total 2 articles about 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 381211-91-2
[1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid

: 67-63-0,8013-70-5
isopropyl alcohol

: 381213-03-2
1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

Guidance literature:: With pyridine; 2-chloro-1,3-dimethylimidazolinium chloride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2006.03.014

Reference yield:

: 381211-85-4
1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene

: 29921-57-1
isopropyl 2-bromoacetate

: 381213-03-2
1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

Guidance literature:: 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene; With 15-crown-5; sodium hydride; In tetrahydrofuran; at 72 ℃; for 1h;

isopropyl 2-bromoacetate; In tetrahydrofuran; at 20 - 72 ℃; for 5.25h;