3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride

Base Information

Chemical Name:3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride
CAS No.:1331774-33-4
Molecular Formula:C₂₆H₃₇N₃O₃*ClH
Molecular Weight:476.059
Hs Code.:

Synonyms:3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride

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Chemical Property of 3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride

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Technology Process of 3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride

There total 5 articles about 3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1331776-03-4
4-[6-butyl-5-(4-cyclohexyloxyphenyl)-1-oxypyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester

: 1331774-33-4
3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride

Guidance literature:: formaldehyd; 4-[6-butyl-5-(4-cyclohexyloxyphenyl)-1-oxypyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester; With acetic acid; In dichloromethane; water; for 1.33333h;

With sodium tris(acetoxy)borohydride; at 20 ℃; for 1.33333h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1331775-53-1
4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]pieridine-1-carboxylic acid tert-butyl ester

: 1331774-33-4
3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 1.25 h / 0 °C

2.1: acetic acid / dichloromethane; water / 1.33 h

2.2: 1.33 h / 20 °C

With acetic acid; In dichloromethane; water;

Reference yield:

: 106-32-1
octanoic acid ethyl ester

: 1331774-33-4
3-butyl-4-(4-cyclohexyloxyphenyl)-6-(1-methylpiperidin-4-yloxy)-pyridazine-2-oxide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate; acetic acid / 12 h / 100 °C

2.1: trichlorophosphate; 2H-Pyridazin-3-one / 0.5 h / 90 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C

3.2: 20 °C

4.1: dichloromethane / 1.25 h / 0 °C

5.1: acetic acid / dichloromethane; water / 1.33 h

5.2: 1.33 h / 20 °C

With 2H-Pyridazin-3-one; potassium tert-butylate; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane; water;