tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate
CAS No.:1333405-41-6
Molecular Formula:C₂₄H₃₁BrN₄O₃S
Molecular Weight:535.505
Hs Code.:

Synonyms:tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate

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Chemical Property of tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate

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Technology Process of tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate

There total 6 articles about tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 545379-56-4
3-benzyl-6-bromo-2-(1-bromopropyl)thieno[3,2-e]pyrimidin-4-one

: 75178-96-0
N-Boc-1,3-diaminopropane

: 1333405-41-6
tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;
DOI:10.1021/jm200629m

Reference yield:

: 1333405-35-8
2-propyl-3H-thieno[3,2-e]pyrimidin-4-one

: 1333405-41-6
tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C

2: bromine; sodium acetate; acetic acid / 0.5 h / 45 °C

3: bromine; sodium acetate; acetic acid / 19.5 h / 55 °C

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

With bromine; sodium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm200629m

Reference yield:

: 896680-70-9
2-(butanoylamino)thiophene-3-carboxamide

: 1333405-41-6
tert-butyl N-[3-[1-(3-benzyl-6-bromo-4-oxothieno[2,3-d]pyrimidin-2-yl)propylamino]propyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / 1 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C

3: bromine; sodium acetate; acetic acid / 0.5 h / 45 °C

4: bromine; sodium acetate; acetic acid / 19.5 h / 55 °C

5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

With bromine; sodium acetate; potassium carbonate; acetic acid; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm200629m