(2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane

Base Information

• Chemical Name: (2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane
• CAS No.: 1132841-45-2
• Molecular Formula: C₁₉H₂₇N₃O
• Molecular Weight: 313.443
• Mol file: 1132841-45-2.mol

Synonyms:(2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane

Chemical Property of (2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane

There total 1 articles about (2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(1S,2R)-1-benzyl-3-(3-dimethylamino-benzylamino)-2-hydroxy-propyl]-carbamic acid t-butyl ester (1132841-13-4) → (2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane (1132841-45-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 84.0%

(2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane (1132841-45-2) → N-[(2S,3R)-4-[(3-dimethylaminophenyl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-5-oxo-1-phenyl-4H-pyrazole-3-carboxamide (1132841-44-1)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; pH=8 - 9;

Reference yield: 72.0%

(2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane (1132841-45-2) + L-Pyroglutamic acid (98-79-3) → (2S)-N-[(2S,3R)-4-[(3-dimethylaminophenyl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-5-oxopyrrolidine-2-carboxamide (1134289-80-7)

Guidance literature:

L-Pyroglutamic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(2R,3S)-1-(3-dimethylamino)benzylamino-2-hydroxy-3-amino-4-phenyl-butane; In N,N-dimethyl-formamide;

upstream raw materials:

[(1S,2R)-1-benzyl-3-(3-dimethylamino-benzylamino)-2-hydroxy-propyl]-carbamic acid t-butyl ester

Downstream raw materials:

C₂₇H₃₉N₅O₃

C₃₁H₃₉N₅O₃

(4S)-N-[(2S,3R)-4-(3-dimethylaminophenyl)methylamino-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1-(2-phenoxyethyl)imidazolidine-4-carboxamide

(4S)-1-benzyl-N-[(2S,3R)-4-(3-dimethylaminophenyl)methylamino-3-hydroxy-1-phenylbutan-2-yl]-4-methyl-2-oxoimidazolidine-4-carboxamide