(1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

Base Information

Chemical Name:(1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate
CAS No.:318957-34-5
Molecular Formula:C₃₁H₃₉NO₄S
Molecular Weight:521.721
Hs Code.:

Synonyms:(1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

Suppliers and Price of (1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

There total 1 articles about (1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38136-29-7
4-methylvaleroyl chloride

: 187324-64-7
(1S,2R)-2-[N-benzyl-N-(mesitylenesulfonyl)amino]-1-phenyl-1-propanol

: 318957-34-5
(1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/ol006560k

Reference yield:

: 318957-34-5
(1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

: 318957-63-0
(2S,3S,6S,7S)-7-(9H-fluoren-9-ylmethoxycarbonylamino)-3,6-dihydroxy-2-isobutyl-9-methyldec-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: Cx₂BOTf; Et₃N / CH₂Cl₂ / 2 h / -78 °C

1.2: CH₂Cl₂ / -78 - 0 °C

2.1: NaOH / methanol; H₂O / 20 °C

3.1: imidazole / dimethylformamide / 24 h / 20 °C

3.2: H₂O / tetrahydrofuran; methanol / 4 h / 20 °C

4.1: (PhO)2PON₃; Et₃N / acetonitrile / 0.5 h / Heating

4.2: CuCl / acetonitrile / 2 h / 20 °C

5.1: AcOH / tetrahydrofuran; H₂O / 0.07 h / 55 °C

6.1: pyridine / 2 h / 20 °C

6.2: pyridine / 1.5 h / 20 °C

7.1: Cl₂(IMes)(PCy₃)Ru=CHPh / toluene / 2 h / 70 °C

8.1: HF / pyridine; tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; sodium hydroxide; Cx₂BOTf; diphenyl phosphoryl azide; hydrogen fluoride; acetic acid; triethylamine; Cl₂(PCy₃)(N,N'-(Mes)2-imidazolidin-2-yl)Ru=CHC₆H₅; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Addition / 1.2: Condensation / 2.1: Hydrolysis / 3.1: silylation / 3.2: Hydrolysis / 4.1: Rearrangement / 4.2: Addition / 5.1: Hydrolysis / 6.1: silylation / 6.2: silylation / 7.1: Cyclization / 8.1: Ring cleavage;
DOI:10.1021/ol006560k

Reference yield:

: 318957-34-5
(1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl 4-methylpentanoate

: (S)-2-{(4S,7S)-7-[(S)-1-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyl]-2,2-dimethyl-4,7-dihydro-[1,3,2]dioxasilepin-4-yl}-4-methyl-pentanethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: Cx₂BOTf; Et₃N / CH₂Cl₂ / 2 h / -78 °C

1.2: CH₂Cl₂ / -78 - 0 °C

2.1: NaOH / methanol; H₂O / 20 °C

3.1: imidazole / dimethylformamide / 24 h / 20 °C

3.2: H₂O / tetrahydrofuran; methanol / 4 h / 20 °C

4.1: (PhO)2PON₃; Et₃N / acetonitrile / 0.5 h / Heating

4.2: CuCl / acetonitrile / 2 h / 20 °C

5.1: AcOH / tetrahydrofuran; H₂O / 0.07 h / 55 °C

6.1: pyridine / 2 h / 20 °C

6.2: pyridine / 1.5 h / 20 °C

7.1: Cl₂(IMes)(PCy₃)Ru=CHPh / toluene / 2 h / 70 °C

With 1H-imidazole; sodium hydroxide; Cx₂BOTf; diphenyl phosphoryl azide; acetic acid; triethylamine; Cl₂(PCy₃)(N,N'-(Mes)2-imidazolidin-2-yl)Ru=CHC₆H₅; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Addition / 1.2: Condensation / 2.1: Hydrolysis / 3.1: silylation / 3.2: Hydrolysis / 4.1: Rearrangement / 4.2: Addition / 5.1: Hydrolysis / 6.1: silylation / 6.2: silylation / 7.1: Cyclization;
DOI:10.1021/ol006560k