3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one

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Chemical Name:3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one
CAS No.:1397263-34-1
Molecular Formula:C₂₆H₁₈Cl₂FN₅O₂
Molecular Weight:522.366
Hs Code.:

Synonyms:3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one

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Chemical Property of 3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one

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Technology Process of 3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one

There total 2 articles about 3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1397263-22-7
C₂₄H₁₇ClFN₅O

: 79-04-9
chloroacetyl chloride

: 1397263-34-1
3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one

Guidance literature:: C₂₄H₁₇ClFN₅O; With triethylamine; In 1,4-dioxane; for 0.5h; Cooling with ice;

chloroacetyl chloride; In 1,4-dioxane; at 0 ℃; Reflux;
DOI:10.1080/00397911.2011.580199

Reference yield:

: 1-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethanone

: 1397263-34-1
3-chloro-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-1-(4-fluorophenyl)-4-methylazetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / 80 °C

2.1: triethylamine / 1,4-dioxane / 0.5 h / Cooling with ice

2.2: 0 °C / Reflux

With acetic acid; triethylamine; In 1,4-dioxane; ethanol;
DOI:10.1080/00397911.2011.580199