N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester

Base Information

• Chemical Name: N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester
• CAS No.: 1026926-22-6
• Molecular Formula: C₁₇H₁₅BrN₄O₂
• Molecular Weight: 387.236
• Mol file: 1026926-22-6.mol

Synonyms:N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester

Chemical Property of N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester

There total 2 articles about N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile (98130-58-6) → N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester (1026926-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 2.5 h / Heating

2: 1.) NaH / 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 30 min

With sodium hydride; In acetonitrile;

DOI:10.1021/jm950444j

Reference yield:

N-(5-Bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester → N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester (1026926-22-6)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 30 min;

DOI:10.1021/jm950444j

Reference yield:

N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester (1026926-22-6) → 4-Amino-7-benzyloxymethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid amide

Guidance literature:

Multi-step reaction with 3 steps

1: NH₃ / methanol / 24 h / Ambient temperature

2: 67 percent / H₂, 1N aq. NaOH / 10percent Pd/C / ethyl acetate; ethanol / 0.5 h / 2585.7 Torr / Ambient temperature

3: 93 percent / NH₄OH, 30percent aq. H₂O₂ / ethanol / 1 h / Ambient temperature

With ammonium hydroxide; sodium hydroxide; ammonia; hydrogen; dihydrogen peroxide; palladium on activated charcoal; In methanol; ethanol; ethyl acetate;

DOI:10.1021/jm950444j

upstream raw materials:

2-amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile

Downstream raw materials:

4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle

4-amino-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle