4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle

Base Information

• Chemical Name: 4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle
• CAS No.: 172043-30-0
• Molecular Formula: C₁₅H₁₂BrN₅O
• Molecular Weight: 358.197
• Mol file: 172043-30-0.mol

Synonyms:4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle

Chemical Property of 4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle

There total 4 articles about 4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester (1026926-22-6) → 4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle (172043-30-0)

Guidance literature:

With ammonia; In methanol; for 24h; Yield given; Ambient temperature;

DOI:10.1021/jm950444j

Reference yield:

2-amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile (98130-58-6) → 4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle (172043-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 2.5 h / Heating

2: 1.) NaH / 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 30 min

3: NH₃ / methanol / 24 h / Ambient temperature

With ammonia; sodium hydride; In methanol; acetonitrile;

DOI:10.1021/jm950444j

Reference yield:

N-(5-Bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester → 4-amino-6-bromo-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle (172043-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 30 min

2: NH₃ / methanol / 24 h / Ambient temperature

With ammonia; sodium hydride; In methanol;

DOI:10.1021/jm950444j

upstream raw materials:

N-(1-Benzyloxymethyl-5-bromo-3,4-dicyano-1H-pyrrol-2-yl)-formimidic acid ethyl ester

2-amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile

Downstream raw materials:

4-amino-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle

4,6-diamino-7-(benzyloxymethyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle