methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate

Base Information

Chemical Name:methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate
CAS No.:947620-69-1
Molecular Formula:C₂₆H₂₄N₄O₅*H₂O
Molecular Weight:490.516
Hs Code.:

Synonyms:methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate

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Chemical Property of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate

Chemical Property:

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Technology Process of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate

There total 8 articles about methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 947620-69-1
methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / triphenylphosphine; palladium dichloride / tetrahydrofuran; water / 18 h / 60 °C

2.1: tetrahydrofuran; methanol; isopropyl alcohol / 15 - 24 h / 90 - 130 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 0.5 h / 0 - 20 °C

3.2: 12 h / 0 °C

4.1: methanol / 20 °C / Heating / reflux

With sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol; 1.1: Suzuki Coupling;

Reference yield:

: 947620-48-6
methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate

: 947620-69-1
methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate

Guidance literature:: In methanol; at 20 ℃; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 3-aminobenzeneboronic acid hemisulfate

: 947620-69-1
methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water; toluene / 48 h / 60 °C

2.1: tetrahydrofuran; methanol; isopropyl alcohol / 15 - 24 h / 90 - 130 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 0.5 h / 0 - 20 °C

3.2: 12 h / 0 °C

4.1: methanol / 20 °C / Heating / reflux

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol; toluene; 1.1: Suzuki Coupling;