E6005

Base Information

Chemical Name:E6005
CAS No.:947620-48-6
Molecular Formula:C₂₆H₂₄N₄O₅
Molecular Weight:472.5
Hs Code.:
Mol file:947620-48-6.mol

Synonyms:methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate

Suppliers and Price of E6005

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RVT501
2.5mg
$ 65.00

TRC
RVT501
25mg
$ 360.00

DC Chemicals
E6005 >98%
100 mg
$ 500.00

DC Chemicals
E6005 >98%
1 g
$ 1800.00

ChemScene
Lotamilast ≥98.0%
10mg
$ 180.00

ChemScene
Lotamilast ≥98.0%
5mg
$ 120.00

ChemScene
Lotamilast ≥98.0%
100mg
$ 948.00

ChemScene
Lotamilast ≥98.0%
50mg
$ 588.00

Chemenu
Methyl4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate 97%
1g
$ 1681.00

Cayman Chemical
E6005
5mg
$ 84.00

Total 21 raw suppliers

Chemical Property of E6005

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

RVT501 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; ) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 in mice.
Uses RVT 501 is a potent and selective inhibitor of human phosphodiesterase 4 (PDE4).

Technology Process of E6005

There total 6 articles about E6005 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

: 234751-30-5
[4-(3-aminophenyl)-6,7-dimethoxyquinazolin-2-yl]methylamine

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 947620-48-6
methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; at 0 ℃; for 14.5h; Inert atmosphere;

Reference yield:

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 947620-48-6
methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / triphenylphosphine / tetrahydrofuran; water / 18 h / 60 °C

2.1: tetrahydrofuran; methanol; isopropyl alcohol / 15 - 24 h / 90 - 130 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; 1,2-dimethoxyethane / 12 h / 0 °C

3.2: 0 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol;

Reference yield:

: 3-aminobenzeneboronic acid hemisulfate

: 947620-48-6
methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water; toluene / 48 h / 60 °C

2.1: tetrahydrofuran; methanol; isopropyl alcohol / 15 - 24 h / 90 - 130 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; 1,2-dimethoxyethane / 12 h / 0 °C

3.2: 0 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol; toluene;