<1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester

Base Information

• Chemical Name: <1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester
• CAS No.: 112796-00-6
• Molecular Formula: C₂₄H₂₆N₄O₆
• Molecular Weight: 466.494
• Mol file: 112796-00-6.mol

Synonyms:<1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester

Chemical Property of <1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of <1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester

There total 1 articles about <1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + 3,6-dihydro-4-methyl-6-(3-nitrophenyl)-2-0x0-1,5(2H)-pyrimidinedicarboxylic acid 5-(1-methylethyl) 1-(4-nitrophenyl) diester (123485-96-1) → <1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester (112796-00-6) + <1(R),6S>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenyl ethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester (112795-99-0)

Guidance literature:

In acetonitrile; for 0.25h; Ambient temperature;

DOI:10.1021/jm00106a048

Reference yield: 77.3%

<1(R),6R>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester (112796-00-6) → <6R>-1-(aminocarbonyl)-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid, 1-methyl ester (112795-98-9)

Guidance literature:

With trifluoroacetic acid; at 75 ℃; for 4h;

DOI:10.1021/jm00106a048

upstream raw materials:

(R)-1-phenyl-ethyl-amine

3,6-dihydro-4-methyl-6-(3-nitrophenyl)-2-0x0-1,5(2H)-pyrimidinedicarboxylic acid 5-(1-methylethyl) 1-(4-nitrophenyl) diester

Downstream raw materials:

<6R>-1-(aminocarbonyl)-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid, 1-methyl ester